| Collectible | Playing card | Prologue — behind the southern dock barrels | Confirmed in the opening Prologue sequence |
| Collectible | Letter scrap | Prologue — under the office desk | Confirmed in the opening Prologue sequence |
| Collectible | Stash box | Prologue — east of the dock | Requires bolt cutters to open |
| Collectible | ATM card | Not yet located | Listed as an inventory item; whether it can be lost or lifted is unanswered (community-reported) |
| Free-roam activity | Basketball | State of Leonida | Confirmed in the gameplay reveal montage |
| Free-roam activity | Pool | State of Leonida | Confirmed in the gameplay reveal montage |
| Free-roam activity | Mini golf | State of Leonida | Confirmed in the gameplay reveal montage |
| Free-roam activity | Weight training | State of Leonida | Confirmed; workouts visibly change character appearance |
| Free-roam activity | Swimming | State of Leonida | Confirmed in the gameplay reveal montage |
| Free-roam activity | Scuba diving | State of Leonida | Confirmed in the gameplay reveal montage |
| Free-roam activity | Kayaking | State of Leonida | Confirmed in the gameplay reveal montage |
| Free-roam activity | Fishing | State of Leonida | Confirmed in the gameplay reveal montage |
| Free-roam activity | Hunting | Mount Kalaga National Park and backwoods | Confirmed; the park is pitched for prime hunting |
| Free-roam activity | Base jumping | State of Leonida | Confirmed in the gameplay reveal montage |
| Free-roam activity | Parachuting | State of Leonida | Confirmed in the gameplay reveal montage |
| Free-roam activity | Shooting ranges | State of Leonida | Confirmed in the gameplay reveal montage |
| Free-roam activity | Stock car racing | State of Leonida | Confirmed in the gameplay reveal montage |
| Free-roam activity | Dirt bike racing | State of Leonida | Confirmed in the gameplay reveal montage |
| Free-roam activity | Jet skis | State of Leonida | Confirmed in the gameplay reveal montage |
| Free-roam activity | Airboats | State of Leonida | Confirmed in the gameplay reveal montage |
| Free-roam activity | Backyard wrestling | State of Leonida | Confirmed; includes WWE-style finishers |
| Side content | Classic Car Collection | Commissioned by Wyman | Track down abandoned classic and project cars and restore them (Ultimate Edition benefit) |
| Side content | PTT Youngin$ Compound | Southside Vice City | Raid the gang compound and escape safely to score special items and contraband (Ultimate Edition benefit) |
| Story progression | Act 1 | Kelly County | Lucia is confined by an ankle monitor; the Kelly County Depot heist funds a hacker to remove it (community-reported) |
| Story progression | Act 2 | Vice Port | The Vice Port Bank Run heist requires three prep missions (community-reported) |
| Story progression | Act 3 | Leonard County Vault | Final mission; the offshore vault heist determines the game's ending (community-reported) |