| Story Completion | Finish the main campaign across all acts | Dual-protagonist story set in Leonida; community walkthroughs describe Act 1–3 progression | Community-reported |
| Gold Medal Missions | Earn gold on story missions by hitting time, accuracy and damage targets | Community walkthroughs cite per-mission gold-medal requirements | Community-reported |
| 100% Completion | Finish the story, side content, collectibles and activities | Community guides describe a 100% completion checklist | Community-reported |
| Collectible Hunter | Find every playing card, letter scrap and stash box | Playing card, letter scrap and stash box collectibles documented in the Prologue | Community-reported |
| Six-Star Wanted | Reach and survive the six-star NOOSE response | Six-star wanted level with NOOSE response confirmed in the gameplay reveal | Unconfirmed (trophy) |
| Hollow-Star Escape | Shake a police search before your description is confirmed | Hollow-star mechanic confirmed — change clothes, swap vehicles or mask up | Unconfirmed (trophy) |
| Relationship Milestone | Grow Jason and Lucia's relationship through shared jobs and texts | Relationship system confirmed; ignoring each other's texts can damage the bond | Unconfirmed (trophy) |
| Activity Tour | Take part in the state's leisure activities | Basketball, pool, mini golf, weight training, fishing, hunting, racing and more confirmed | Unconfirmed (trophy) |
| Vehicle Acquisition | Break into cars across every security tier | Tiered vehicle security with Slim Jim and key cloner confirmed; WAINK app scans value and alarms | Unconfirmed (trophy) |
| Heist Specialist | Pull off heists with full prep and clean escapes | Community guides describe multi-step prep missions for Act 2 and Act 3 heists | Community-reported |
| Classic Car Collection | Restore abandoned classic cars for Wyman | Wyman's Classic Car Collection benefit listed with the Ultimate Edition | Unconfirmed (trophy) |
| Map Mastery | Explore all six regions of Leonida | Six confirmed regions: Vice City, Leonida Keys, Grassrivers, Port Gellhorn, Ambrosia, Mount Kalaga | Unconfirmed (trophy) |